Eukaryotic Translation Initiation Factor 4B

EIF4Bgene

EIF4B phosphorylation indicates translational stress response in ischemic cardiomyocytes.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencelow

RationalePhosphorylated protein elevated in MI model; translation stress marker.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000063046

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable