ELP3
ELP3geneELP3, involved in DNA replication and cellular stress responses, contributes to myocardial infarction pathology through mechanisms not directly on the atherothrombotic cascade.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleLinked to DNA replication and MI pathology; off-cascade mechanism.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Spontaneous Abortion and Myocardial Infarction: A Mendelian Randomization Investigation and Transcriptomic Analysis.Global heart · 2025 · PMID 39925840 · doi