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Endoglin
Pathway / Endothelial activation & erosion

Endoglin

ENGprotein

Endoglin regulates endothelial function and vascular remodeling; elevated levels reflect endothelial activation and plaque neoangiogenesis associated with atherosclerosis progression.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial dysfunction; angiogenesis and plaque neoangiogenesis; lesion progression.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000106991

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
72
E — evidence strength
60
T1DI (composite)
10
Specificity differential (R−C)-51.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressn/a
Coverage: 2/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 17 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(4)