Receptor tyrosine-protein kinase erbB-4
ERBB4geneERBB4, activated by neuregulin-1, suppresses endothelial-to-mesenchymal transition and promotes endothelial cell survival during vascular injury and atherosclerosis.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleERBB4 signaling protects endothelial cells from EndMT and dysfunction.
Druggability
DruggableYes
Known drugs / candidates15
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000178568
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition.BioMed research international · 2019 · PMID 31317035 · doi