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Fas
Pathway / Myocardial injury (shared endpoint)

Fas

FASprotein

Fas mediates apoptosis in both cardiomyocytes and endothelial cells, contributing to ischemic injury and vascular dysfunction.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleDeath-receptor-mediated apoptosis in cardiomyocytes and endothelial cells during MI; ischemic injury and endothelial damage.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000026103

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
53
A — assay feasibility
68
E — evidence strength
42
T1DI (composite)
16
Specificity differential (R−C)+13.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduralmag 2
4bstent thrombosismag 1
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 5/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 18 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(3)