FHL3

FHL3gene

FHL3 is a CAD-variant-regulated smooth muscle gene that modulates vascular inflammation and structural adaptation in atherosclerosis.

Pathway placement

Cascade stepPlaque inflammation

Confidencelow

RationaleCAD-variant SMC regulator; involved in vascular stress response.

Also acts inEndothelial activation/erosion

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000183386

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable