Four and a half LIM domains 5

FHL5gene

LIM-domain protein regulating vascular remodeling and calcification that influences atherosclerotic plaque stability and cap integrity.

Pathway placement

Cascade stepEndothelial activation & erosion

Confidencemedium

RationaleVascular remodeling and calcification; endothelial and smooth-muscle function in plaque stability.

Also acts inCap degradation / rupture

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000112214

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

GWAS associations

Traits: myocardial infarction