FoxO1
FOXO1geneFoxO1 transcription-factor dysregulation in coronary artery disease impairs endothelial function and promotes atherosclerotic vascular remodeling.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial-function regulator; miR-145 target; CAD/metabolic disease marker; modulates vascular homeostasis.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000150907
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I41
C — confounder / Type-II83
A — assay feasibility52
E — evidence strength30
T1DI (composite)5
Specificity differential (R−C)-41.9
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(3)
- Identification of biomarkers associated with coronary artery disease and non-alcoholic fatty liver disease by bioinformatics analysis and machine learning.Scientific reports · 2025 · PMID 39875572 · doi
- MicroRNA-145 is involved in endothelial cell dysfunction and acts as a promising biomarker of acute coronary syndrome.European journal of medical research · 2020 · PMID 32178736 · doi
- Posttranslational modulation of FoxO1 contributes to cardiac remodeling in post-ischemic heart failure.Atherosclerosis · 2016 · PMID 27105158 · doi
Omics datasets(2)
- GSE313931GEOFOXO1 integrates endothelial hemodynamic, inflammatory and metabolic pathways in atherosclerosis [OSS]
- GSE313932GEOFOXO1 integrates endothelial hemodynamic, inflammatory and metabolic pathways in atherosclerosis [LSS]