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Ferritin
Pathway / Off-pathway / systemic markers

Ferritin

FTH1protein

Ferritin is a systemic marker of oxidative stress and hemolysis associated with myocardial infarction risk and adverse outcomes.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleSystemic iron-metabolism and oxidative-stress marker; associated with MACE risk.
Also acts inMyocardial injury
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
53
A — assay feasibility
84
E — evidence strength
95
T1DI (composite)
25
Specificity differential (R−C)-38.3
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 3
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmiamag 1
2hypoxemia / respiratory failuremag 0
2hypertensive emergencymag 0
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 3
4aPCI-related periproceduralmag 1
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 10/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 15 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST)
Method / principle
Chemiluminescent/immunoturbidimetric immunoassay
Reagent / substrate
Anti-ferritin antibody pair/latex
Platform
Automated analyzer
Turnaround · availability
Routine · Universal

Literature evidence(2)