Ferritin

FTH1protein

Ferritin is a systemic marker of oxidative stress and hemolysis associated with myocardial infarction risk and adverse outcomes.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencemedium

RationaleSystemic iron-metabolism and oxidative-stress marker; associated with MACE risk.

Also acts inMyocardial injury

Druggability

Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresIndeterminate

R — rupture / Type-I

—

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-29.4

Confounder panel (Type-II drivers)

1sepsis / systemic inflammationmag 3

2anemia / acute blood lossn/a

3hypovolemia / dehydrationmag 2

4tachyarrhythmiamag 1

5hypoxemia / respiratory failuremag 0

6hypertensive emergencymag 0

7high-demand / peri-operative stressmag 2

Coverage: 6/7 confounders with evidence

Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Validated clinical assay

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST)

Method / principle

Chemiluminescent/immunoturbidimetric immunoassay

Reagent / substrate

Anti-ferritin antibody pair/latex

Platform

Automated analyzer

Turnaround · availability

Routine · Universal