GTP Cyclohydrolase I

GCH1gene

GTP cyclohydrolase I sustains nitric oxide production in endothelium, preserving vasodilation and reducing plaque inflammation and endothelial activation.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleRegulates tetrahydrofolate and nitric oxide synthesis; improves endothelial function.

Also acts inEndothelial activation/erosion

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000131979

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

Identification of gene variants related to the nitric oxide pathway in patients with acute coronary syndrome.
Gene · 2015 · PMID 26232608 · doi