GDNF family receptor alpha-like

GFRALprotein

GFRAL mediates GDF-15 signaling in systemic metabolic stress and cardiometabolic homeostasis distinct from atherothrombotic rupture.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencelow

RationaleGDF-15 receptor; systemic metabolic and stress-response signaling; not plaque-rupture-pathway specific.

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)