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Glutamic oxaloacetic transaminase 2
Pathway / Myocardial injury (shared endpoint)

Glutamic oxaloacetic transaminase 2

GOT2protein

Mitochondrial transaminase release during myocardial necrosis indicating cardiac cell death in acute MI.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleMitochondrial enzyme; released during cardiomyocyte necrosis and ischemia-reperfusion injury.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000125166

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.007
Open Targets association (NSTEMI)

Literature evidence(2)