GPI-anchored high-density lipoprotein-binding protein 1

GPIHBP1protein

GPIHBP1 anchors lipoprotein lipase at the endothelial surface, regulating triglyceride-rich lipoprotein clearance and lipid substrate retention.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencemedium

RationaleEndothelial lipolysis platform; regulates local triglyceride hydrolysis and remnant lipoprotein handling.

Also acts inEndothelial activation/erosion

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000277494

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)