GUCY1A1

GUCY1A1gene

GUCY1A1 CAD-associated variants impair nitric-oxide signaling in the endothelium, promoting dysfunction and atherothrombotic risk.

Pathway placement

Cascade stepEndothelial activation & erosion

Confidencemedium

RationaleGuanylate cyclase mediates endothelial NO signaling; CAD GWAS locus suggests endothelial dysfunction role.

Druggability

DruggableYes

Known drugs / candidates15

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000164116

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

0.695

Open Targets association (myocardial_infarction)

GWAS associations

Traits: myocardial infarction