Guanylate cyclase soluble subunit alpha 2
GUCY1A2geneSoluble guanylate cyclase mediates NO-cGMP vasodilation; supply-demand / endothelial function, not atherothrombosis.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleNitric oxide signaling; vascular tone regulation, not atherothrombotic cascade.
Druggability
DruggableYes
Known drugs / candidates15
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000152402
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.550
Open Targets association (myocardial_infarction)
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.