Guanylate cyclase 1 soluble subunit beta-1
GUCY1B1geneGUCY1B1 is the beta subunit of soluble guanylate cyclase; NO-sGC-cGMP signaling promotes vasodilation and endothelial health, limiting atherothrombosis.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleNitric oxide signaling; endothelial function / vasodilation.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates15
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000061918
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.586
Open Targets association (myocardial_infarction)
1
GWAS associations
Traits: myocardial infarction
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.