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H19
Pathway / Plaque inflammation

H19

H19rna

H19 circulating levels reflect apoptosis-autophagy signaling in plaque macrophages, integrating inflammation and matrix destabilization.

Pathway placement
Cascade stepPlaque inflammation
Confidencelow
RationaleCirculating apoptosis-autophagy lncRNA; dysregulation reflects macrophage apoptosis and plaque inflammation.
Also acts inCap degradation / rupture
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000130600

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — non-Type-I
67
A — assay feasibility
50
E — evidence strength
25
T1DI (composite)
4
Specificity differential (R−C)-43.5
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood (transcript)
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)

Literature evidence(1)