Histone Deacetylase 9
HDAC9geneHDAC9 genetic variants regulate histone acetylation and chromatin remodeling to modulate atherosclerotic plaque inflammation and stability.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleCAD risk locus; modulates plaque stability and atherosclerotic inflammation.
Also acts inCap degradation / rupture
Druggability
DruggableYes
Known drugs / candidates12
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000048052
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I20
C — confounder / Type-II40
A — assay feasibility52
E — evidence strength16
T1DI (composite)3
Specificity differential (R−C)-20
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(3)
- The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1.PLoS genetics · 2022 · PMID 35714152 · doi
- Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.Circulation research · 2020 · PMID 32546048 · doi
- Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke.BMC medicine · 2012 · PMID 22776031 · doi