HDHD2
HDHD2proteinHDHD2 functions as a circulating protective factor reducing myocardial infarction risk, likely through anti-inflammatory or lipid-modulating activity.
Pathway placement
Cascade stepPlaque inflammation
Confidencelow
RationalePlasma protective factor; likely anti-inflammatory or plaque-stabilizing.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000167220
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- Identifying potential drug targets for myocardial infarction through Mendelian randomization.PloS one · 2024 · PMID 39715222 · doi