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Haptoglobin
Pathway / Plaque inflammation

Haptoglobin

HPprotein

Haptoglobin is an acute-phase diagnostic biomarker for myocardial infarction, responding to hemolysis and vascular inflammation in atherothrombotic events.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleHaptoglobin is an acute-phase marker and core MI gene; binds hemoglobin in oxidative stress.
Also acts inSystemic / off-pathway, Myocardial injury
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000257017

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
84
E — evidence strength
33
T1DI (composite)
7
Specificity differential (R−C)-52
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 3
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuren/a
6hypertensive emergencymag 1
7high-demand / peri-operative stressmag 2
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 8 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST)
Method / principle
Immunoturbidimetric/nephelometric
Reagent / substrate
Anti-haptoglobin antibody-latex
Platform
Automated analyzer
Turnaround · availability
Routine · Universal

Literature evidence(7)