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Haptoglobin
Pathway / Plaque inflammation

Haptoglobin

HPprotein

Haptoglobin is an acute-phase diagnostic biomarker for myocardial infarction, responding to hemolysis and vascular inflammation in atherothrombotic events.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleHaptoglobin is an acute-phase marker and core MI gene; binds hemoglobin in oxidative stress.
Also acts inSystemic / off-pathway, Myocardial injury
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000257017

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
57
A — assay feasibility
84
E — evidence strength
33
T1DI (composite)
8
Specificity differential (R−C)-42.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 3
2anemia / acute blood lossmag 2
2hypovolemia / dehydrationn/a
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuren/a
2hypertensive emergencymag 1
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 0
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedmag 2
Coverage: 7/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 10 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST)
Method / principle
Immunoturbidimetric/nephelometric
Reagent / substrate
Anti-haptoglobin antibody-latex
Platform
Automated analyzer
Turnaround · availability
Routine · Universal

Literature evidence(7)