Heat Shock Factor 2 Binding Protein
HSF2BPgeneHSF2BP variants associate with CAD susceptibility through poorly characterized stress-response or regulatory mechanisms not directly on the atherothrombotic cascade.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleCAD susceptibility gene; stress-response pathway; mechanism in MI unclear, placed off-pathway.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Exploring the dark genome: implications for precision medicine.Mammalian genome : official journal of the International Mammalian Genome Society · 2019 · PMID 31270560 · doi