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Heat shock protein A8
Pathway / Myocardial injury (shared endpoint)

Heat shock protein A8

HSPA8protein

HSPA8 regulates protein quality control and ferroptotic cardiomyocyte death in MIRI.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleFerroptosis and eNOS degradation marker; myocardial ischemia/reperfusion injury.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000109971

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — non-Type-I
59
A — assay feasibility
72
E — evidence strength
22
T1DI (composite)
5
Specificity differential (R−C)-35.5
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(2)