Heat shock protein A8
HSPA8proteinHSPA8 regulates protein quality control and ferroptotic cardiomyocyte death in MIRI.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleFerroptosis and eNOS degradation marker; myocardial ischemia/reperfusion injury.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000109971
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I23
C — confounder / Type-II58
A — assay feasibility72
E — evidence strength21
T1DI (composite)5
Specificity differential (R−C)-34.4
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Single-cell sequencing combined with transcriptomics and in vivo and in vitro analysis reveals the landscape of ferroptosis in myocardial ischemia-reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024 · PMID 39520298 · doi
- , a coronary artery disease risk gene, mediates endothelial dysfunction.Frontiers in immunology · 2022 · PMID 36091033 · doi