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Intercellular Adhesion Molecule 1
Pathway / Endothelial activation & erosion

Intercellular Adhesion Molecule 1

ICAM1protein

sICAM-1 reflects endothelial activation and leukocyte recruitment to atherosclerotic plaques and coronary injury sites.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleSoluble ICAM-1 is an endothelial activation marker and adhesion molecule.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000090339

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
C — confounder / Type-II
61
A — assay feasibility
72
E — evidence strength
73
T1DI (composite)
14
Specificity differential (R−C)-46.1
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 1
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 2
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 20 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA
Reagent / substrate
Anti-ICAM-1 (CD54) antibody pair
Platform
ELISA plate
Turnaround · availability
Research · Research

Literature evidence(43)

Showing 40 of 43 linked references.