Intercellular Adhesion Molecule 1
ICAM1proteinsICAM-1 reflects endothelial activation and leukocyte recruitment to atherosclerotic plaques and coronary injury sites.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleSoluble ICAM-1 is an endothelial activation marker and adhesion molecule.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000090339
Type I vs Type II discrimination
ScoresType-II-associated
R — rupture / Type-I—
C — confounder / Type-II61
A — assay feasibility72
E — evidence strength73
T1DI (composite)14
Specificity differential (R−C)-46.1
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 1
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 2
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 20 supporting references. See the discrimination table for all markers.
Assay & specimen
Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA
Reagent / substrate
Anti-ICAM-1 (CD54) antibody pair
Platform
ELISA plate
Turnaround · availability
Research · Research
Literature evidence(43)
- Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells.Microvascular research · 2024 · PMID 38307406 · doi
- Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism.World journal of microbiology & biotechnology · 2024 · PMID 38727952 · doi
- Novel Insight into Inflammatory Pathways in Acute Pulmonary Embolism in Humans.Archivum immunologiae et therapiae experimentalis · 2024 · PMID 39466143 · doi
- Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.PLoS genetics · 2023 · PMID 36928188 · doi
- Plasma Interleukin-6 (IL-6), Angiopoietin-2, and C-Reactive Protein Levels Predict Subsequent Type 1 Myocardial Infarction in Persons With Treated HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2023 · PMID 37018921 · doi
- Synopsis of Biomarkers of Atheromatous Plaque Formation, Rupture and Thrombosis in the Diagnosis of Acute Coronary Syndromes.Current cardiology reviews · 2022 · PMID 35410616 · doi
- Inflammatory biomarkers and risk of cardiovascular events in patients undergoing coronary angiography.American heart journal · 2022 · PMID 35753356 · doi
- Effect of invasive therapeutic coronary interventions on endothelial cell activation and thrombin generation in patients with chronic total coronary occlusion.Thrombosis research · 2022 · PMID 35908382 · doi
- , a coronary artery disease risk gene, mediates endothelial dysfunction.Frontiers in immunology · 2022 · PMID 36091033 · doi
- A novel circulating biomarker lnc-MALAT1 for acute myocardial infarction: Its relationship with disease risk, features, cytokines, and major adverse cardiovascular events.Journal of clinical laboratory analysis · 2022 · PMID 36378551 · doi
- The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease.Thrombosis and haemostasis · 2022 · PMID 36588289 · doi
- Dysregulation of serum miR-361-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients.BMC cardiovascular disorders · 2021 · PMID 33546604 · doi
- Weighted gene co-expression network analysis identifies specific modules and hub genes related to coronary artery disease.Scientific reports · 2021 · PMID 33758323 · doi
- Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19.Frontiers in immunology · 2021 · PMID 34491250 · doi
- Targeted gene expression analysis of human deep veins.Journal of vascular surgery. Venous and lymphatic disorders · 2020 · PMID 32860957 · doi
- Novel biomarkers in the prognosis of patients with atherosclerotic coronary artery disease.Revista portuguesa de cardiologia · 2020 · PMID 33239161 · doi
- Integrated analysis of gene expression changes associated with coronary artery disease.Lipids in health and disease · 2019 · PMID 30961613 · doi
- Pinocembrin protects endothelial cells from oxidized LDL-induced injury.Cytokine · 2018 · PMID 29914794 · doi
- Associations Between Psychological Constructs and Cardiac Biomarkers After Acute Coronary Syndrome.Psychosomatic medicine · 2017 · PMID 27749683 · doi
- Biomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants.International archives of occupational and environmental health · 2017 · PMID 28124139 · doi
- Integrity(®) bare-metal coronary stent-induced platelet and endothelial cell activation results in a higher risk of restenosis compared to Xience(®) everolimus-eluting stents in stable angina patients.Platelets · 2016 · PMID 26765134 · doi
- Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Humans.Diabetes · 2015 · PMID 25695946 · doi
- Identification of CAD candidate genes in GWAS loci and their expression in vascular cells.Journal of lipid research · 2013 · PMID 23667179 · doi
- The association of ventricular tachycardia and endothelial dysfunction in the setting of acute myocardial infarction with ST elevation.Medical science monitor : international medical journal of experimental and clinical research · 2013 · PMID 24253420 · doi
- Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users.Thrombosis research · 2011 · PMID 21601240 · doi
- Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2009 · PMID 19171469 · doi
- Markers of endothelial dysfunction after cardiac surgery: soluble forms of vascular-1 and intercellular-1 adhesion molecules.Medicina (Kaunas, Lithuania) · 2009 · PMID 19605962
- Inflammatory systemic biomarkers in setting acute coronary syndromes--effects of the diurnal variation.Current drug targets · 2009 · PMID 19860643 · doi
- Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study.European heart journal · 2008 · PMID 18621771 · doi
- Prediction of atherosclerotic plaque ruptures with high-frequency ultrasound imaging and serum inflammatory markers.American journal of physiology. Heart and circulatory physiology · 2007 · PMID 17704293 · doi
- Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium.Thrombosis and haemostasis · 2007 · PMID 17938804
- Interleukin-6 correlates with endothelial dysfunction in young post-myocardial infarction patients.Cardiology · 2006 · PMID 16864964 · doi
- Evaluation of markers of endothelial damage in cases of young myocardial infarction.Atherosclerosis · 2005 · PMID 15910865 · doi
- [HIV infection, antiretroviral therapy, and endothelium].Herz · 2005 · PMID 16170677 · doi
- Systemic inflammatory markers in acute coronary syndrome: association with cardiovascular risk factors and effect of early lipid lowering.Coronary artery disease · 2005 · PMID 16205449 · doi
- [Endothelial adhesion molecules ICAM-1, VCAM-1 and E-selectin in patients with acute coronary syndrome].Revista espanola de cardiologia · 2003 · PMID 12605758 · doi
- Increased soluble platelet/endothelial cell adhesion molecule-1 in the early stages of acute coronary syndromes.International journal of cardiology · 2003 · PMID 12957760 · doi
- Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-selectin mediate leukocyte binding to ischemic heart in humans.Journal of the American College of Cardiology · 2000 · PMID 10898423 · doi
- Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk.Journal of the American College of Cardiology · 2000 · PMID 10933352 · doi
- Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells.Blood · 1999 · PMID 10216090
Showing 40 of 43 linked references.