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Intercellular Adhesion Molecule 1
Pathway / Endothelial activation & erosion

Intercellular Adhesion Molecule 1

ICAM1protein

sICAM-1 reflects endothelial activation and leukocyte recruitment to atherosclerotic plaques and coronary injury sites.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleSoluble ICAM-1 is an endothelial activation marker and adhesion molecule.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000090339

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
61
A — assay feasibility
72
E — evidence strength
73
T1DI (composite)
14
Specificity differential (R−C)-45.6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuremag 1
2hypertensive emergencymag 2
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 1
4bstent thrombosismag 2
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 11/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 27 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA
Reagent / substrate
Anti-ICAM-1 (CD54) antibody pair
Platform
ELISA plate
Turnaround · availability
Research · Research

Literature evidence(43)

Showing 40 of 43 linked references.