Insulin-like Growth Factor Binding Protein 6
IGFBP6proteinIGFBP6 regulates insulin-like growth factor availability during plaque inflammation and fibrous-cap degradation.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleIGF signaling modulates plaque inflammation and extracellular matrix remodeling.
Also acts inCap degradation / rupture
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000167779
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2024 · PMID 38450510 · doi
- Discovery of potential plasma protein biomarkers for acute myocardial infarction via proteomics.Journal of thoracic disease · 2019 · PMID 31656670 · doi
Omics datasets(1)
- GSE265787GEOEndothelial IGFBP6 Suppresses Vascular Inflammation and Atherosclerosis