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Interleukin-10
Pathway / Plaque inflammation

Interleukin-10

IL10protein

Interleukin-10 is a protective anti-inflammatory cytokine that restrains atherosclerotic plaque inflammation and macrophage activation; its reduction by oxidized lipids and inflammatory signals is associated with plaque destabilization and MI.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleAnti-inflammatory cytokine that suppresses plaque inflammation; reduced levels associate with plaque instability and MI risk.
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000136634

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
—
C — confounder / Type-II
33
A — assay feasibility
72
E — evidence strength
86
T1DI (composite)
25
Specificity differential (R−C)-18.3
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuremag 0
6hypertensive emergencymag 0
7high-demand / peri-operative stressmag 1
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(28)