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ST2
Pathway / Off-pathway / systemic markers

ST2

IL1RL1protein

ST2 signals myocardial stress and remodeling response post-infarction, serving as an off-pathway hemodynamic/mechanical stress indicator.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleCardiac remodeling, mechanical stress, and neurohormonal/hemodynamic response marker.
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000115602

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
62
A — assay feasibility
84
E — evidence strength
66
T1DI (composite)
29
Specificity differential (R−C)+4.8
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossmag 2
2hypovolemia / dehydrationn/a
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuren/a
2hypertensive emergencymag 1
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 2
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 7/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 10 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (Presage ST2 ELISA)
Reagent / substrate
Anti-ST2 antibody pair
Platform
ELISA / automated
Turnaround · availability
Send-out · FDA-cleared (Presage ST2)

Literature evidence(21)