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ST2
Pathway / Off-pathway / systemic markers

ST2

IL1RL1protein

ST2 signals myocardial stress and remodeling response post-infarction, serving as an off-pathway hemodynamic/mechanical stress indicator.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleCardiac remodeling, mechanical stress, and neurohormonal/hemodynamic response marker.
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000115602

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
56
A — assay feasibility
84
E — evidence strength
66
T1DI (composite)
31
Specificity differential (R−C)+11.1
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuren/a
6hypertensive emergencymag 1
7high-demand / peri-operative stressn/a
Coverage: 3/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 8 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (Presage ST2 ELISA)
Reagent / substrate
Anti-ST2 antibody pair
Platform
ELISA / automated
Turnaround · availability
Send-out · FDA-cleared (Presage ST2)

Literature evidence(21)