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IL-6 Receptor
Pathway / Plaque inflammation

IL-6 Receptor

IL6Rgene

IL-6 receptor mediates IL-6 pro-inflammatory and myocardial-injury signaling in atherosclerosis and acute MI.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleIL-6 signaling receptor; drives atherosclerotic inflammation and myocardial injury response.
Also acts inMyocardial injury
Druggability
DruggableYes
Known drugs / candidates5
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000160712

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
60
A — assay feasibility
84
E — evidence strength
49
T1DI (composite)
22
Specificity differential (R−C)+7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 3
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 2
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedmag 0
Coverage: 5/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA
Reagent / substrate
Anti-IL6R antibody pair
Platform
ELISA plate
Turnaround · availability
Research · Research

Human genetic evidence

0.503
Open Targets association (myocardial_infarction)
4
GWAS associations
Traits: myocardial infarction

Literature evidence(5)