IRAK3

IRAK3gene

IRAK3 negatively regulates TLR-driven inflammatory signaling, controlling monocyte activation and plaque inflammation in acute coronary events.

Pathway placement

Cascade stepPlaque inflammation

Confidencehigh

RationaleInterleukin-1 receptor-associated kinase 3; TLR/IL-1R signaling regulator attenuating innate immune activation.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000090376

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable