JCAD
JCADgeneJCAD directly drives endothelial dysfunction and atherosclerotic plaque formation, contributing to Type 1 MI risk through endothelial erosion and CAD.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationalePromotes endothelial dysfunction and atherosclerosis; shared CAD locus.
Also acts inVascular inflammation
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000165757
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.488
Open Targets association (myocardial_infarction)
2
GWAS associations
Traits: myocardial infarction
Literature evidence(2)
- Identification of Phosphorylation Associated SNPs for Blood Pressure, Coronary Artery Disease and Stroke from Genome-wide Association Studies.Current molecular medicine · 2019 · PMID 31456518 · doi
- The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis.European heart journal · 2019 · PMID 31539914 · doi