Pathway / Myocardial injury (shared endpoint)

KBTBD10

KBTBD10gene

KBTBD10 is a cardiac/muscle-specific ubiquitin ligase elevated during myocardial ischemic injury and proteolytic remodeling in acute myocardial infarction.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleCardiac/muscle E3 ligase upregulated in myocardial damage.

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction.
Clinical science (London, England : 1979) · 2015 · PMID 25599194 · doi