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VEGFR-2 (KDR)
Pathway / Endothelial activation & erosion

VEGFR-2 (KDR)

KDRprotein

VEGFR-2 on circulating endothelial cells and EPCs marks endothelial activation, injury and angiogenic response in Type 1 MI.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial progenitor cell marker; endothelial activation.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates75
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000128052

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
50
A — assay feasibility
72
E — evidence strength
28
T1DI (composite)
12
Specificity differential (R−C)+16.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 1
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedn/a
Coverage: 2/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 4 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(9)