Krüppel-like Factor 2
KLF2geneKLF2 downregulation impairs endothelial shear-stress sensing and homeostasis, promoting endothelial erosion and Type 1 MI.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleEndothelial-cell-viability regulator; mechanotransduction and flow-response control; targeted by miR-32-5p.
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000127528
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I55
C — confounder / Type-II62
A — assay feasibility52
E — evidence strength25
T1DI (composite)6
Specificity differential (R−C)-6.7
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(2)
- Silence of miR-32-5p promotes endothelial cell viability by targeting KLF2 and serves as a diagnostic biomarker of acute myocardial infarction.Diagnostic pathology · 2020 · PMID 32127011 · doi
- Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.Proceedings of the National Academy of Sciences of the United States of America · 2018 · PMID 30429326 · doi