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Lactate dehydrogenase
Pathway / Myocardial injury (shared endpoint)

Lactate dehydrogenase

LDHAprotein

Lactate dehydrogenase released from ischemic cardiomyocytes and endothelial cells serves as an acute myocardial injury and tissue-damage marker.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleMyocardial and endothelial cell injury marker; ischemic damage indicator.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000134333

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
56
A — assay feasibility
72
E — evidence strength
50
T1DI (composite)
11
Specificity differential (R−C)-40.6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduralmag 2
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedn/a
Coverage: 3/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 8 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma (avoid hemolysis)
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Enzymatic kinetic (lactate→pyruvate, IFCC)
Reagent / substrate
L-lactate + NAD+ → pyruvate + NADH, read 340 nm
Platform
Automated chemistry analyzer
Turnaround · availability
Routine · Universal

Literature evidence(12)