Galectin-4
LGALS4proteinGalectin-4 is a lectin mediating cell–cell interactions and immune regulation, with elevated levels associated with coronary artery disease risk.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleSystemic inflammation and cell-adhesion marker elevated in CAD.
Also acts inVascular inflammation, Endothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial.ESC heart failure · 2023 · PMID 37939716 · doi
- Novel multi-marker proteomics in phenotypically matched patients with ST-segment myocardial infarction: association with clinical outcomes.Journal of thrombosis and thrombolysis · 2021 · PMID 34708315 · doi