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Leukotriene A4 hydrolase
Pathway / Plaque inflammation

Leukotriene A4 hydrolase

LTA4Hprotein

LTA4H catalyzes leukotriene production, amplifying neutrophil recruitment to the atherosclerotic lesion and promoting plaque inflammation and thrombotic response.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleLeukotriene pathway drives neutrophil recruitment and platelet-leukocyte interaction.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000111144

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
33
C — confounder / Type-II
40
A — assay feasibility
72
E — evidence strength
17
T1DI (composite)
6
Specificity differential (R−C)-6.8
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)