LY96

LY96gene

LY96 amplifies TLR-mediated monocyte and endothelial activation, intensifying plaque inflammation and atherothrombotic susceptibility.

Pathway placement

Cascade stepPlaque inflammation

Confidencehigh

RationaleLymphocyte antigen 96; co-receptor for TLR4 and TLR2, essential for lipopolysaccharide and pathogen sensing.

Druggability

DruggableYes

Known drugs / candidates2

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000154589

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable