Mitogen-Activated Protein Kinase Kinase Kinase 14

MAP3K14gene

MAP3K14 activates non-canonical NF-κB signaling in plaque macrophages and vascular inflammation.

Pathway placement

Cascade stepPlaque inflammation

Confidencelow

RationaleNon-canonical NF-κB pathway; plaque inflammatory signaling.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000006062

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable