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JNK1
Pathway / Plaque inflammation

JNK1

MAPK8protein

c-Jun N-terminal kinase-1 amplifies vascular inflammation and platelet activation during plaque destabilization.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleJNK signaling drives inflammatory cytokine production and platelet activation in atherothrombotic inflammation.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000107643

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
45
C — non-Type-I
69
A — assay feasibility
72
E — evidence strength
29
T1DI (composite)
8
Specificity differential (R−C)-24
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)