MIA3

MIA3gene

MIA3 downstream of ADTRP modulates leukocyte adhesion molecule trafficking and endothelial activation, reducing plaque inflammation.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleADTRP effector regulating endocytic trafficking and monocyte adhesion; suppresses inflammatory cell recruitment.

Also acts inEndothelial activation/erosion

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000154305

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

0.461

Open Targets association (myocardial_infarction)

GWAS associations

Traits: myocardial infarction