MIAT (myocardial-infarction-associated transcript)
MIATrnaLong non-coding RNA dysregulated in atherosclerosis and myocardial infarction, modulating vascular inflammation and plaque stability.
Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleMI-associated lncRNA; atherosclerosis & plaque inflammation; reduced in STEMI platelets.
Also acts inLipid entry/oxidation
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000225783
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood (transcript)
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(3)
- Association of N-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts.Cell death & disease · 2019 · PMID 31797919 · doi
- Long non-coding RNA MIAT in development and disease: a new player in an old game.Journal of biomedical science · 2018 · PMID 29534728 · doi
- Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.Platelets · 2015 · PMID 26367242 · doi