microRNA-145
MIR145rnamiR-145 dysregulation promotes endothelial dysfunction during plaque evolution and predicts post-MI adverse outcomes.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleRegulates endothelial function; dysregulated in endothelial dysfunction and post-MI remodeling.
Also acts inMyocardial injury
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000276365
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I43
C — confounder / Type-II65
A — assay feasibility50
E — evidence strength25
T1DI (composite)5
Specificity differential (R−C)-22
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(2)
- MicroRNA-145 is involved in endothelial cell dysfunction and acts as a promising biomarker of acute coronary syndrome.European journal of medical research · 2020 · PMID 32178736 · doi
- Prediction of long-term outcome after acute myocardial infarction using circulating miR-145.Scandinavian journal of clinical and laboratory investigation · 2014 · PMID 25465803 · doi