Methionine Sulfoxide Reductase A
MSRAgeneMethionine sulfoxide reductase A reduces oxidative stress in atherosclerotic plaques and ischemic myocardium, limiting inflammation-driven plaque destabilization and cardiomyocyte damage.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleOxidative stress reducer; protects against plaque inflammation and cardiomyocyte injury.
Also acts inMyocardial injury
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000175806
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I26
C — confounder / Type-II51
A — assay feasibility52
E — evidence strength19
T1DI (composite)4
Specificity differential (R−C)-24.7
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Identification of gene variants related to the nitric oxide pathway in patients with acute coronary syndrome.Gene · 2015 · PMID 26232608 · doi