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Cardiac Myosin-Binding Protein C
Pathway / Myocardial injury (shared endpoint)

Cardiac Myosin-Binding Protein C

MYBPC3protein

Cardiac myosin-binding protein C is released into circulation upon cardiomyocyte necrosis, marking myocardial injury in acute MI.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencehigh
RationaleMyocardial injury marker released from damaged cardiomyocytes during ischemic necrosis.
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000134571

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
67
A — assay feasibility
68
E — evidence strength
67
T1DI (composite)
26
Specificity differential (R−C)+12
Direct evidence: higher in Type I (D=+1)
cMyBP-C levels measured in both T1MI and T2MI cohorts; higher discrimination value for T1MI vs T2MI when combined with other biomarkers.
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuren/a
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 1/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 7 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA / research immunoassay
Reagent / substrate
Anti-cMyBP-C antibody pair
Platform
ELISA/research
Turnaround · availability
Research · Research-only

Literature evidence(4)