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Nuclear Receptor Coactivator 4
Pathway / Myocardial injury (shared endpoint)

Nuclear Receptor Coactivator 4

NCOA4protein

NCOA4 is the selective autophagy receptor for ferritin degradation, controlling labile iron pools and oxidative stress in ischemic cardiomyocytes.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencehigh
RationaleCore ferritinophagy cargo receptor; regulates iron homeostasis in ischemic myocardium.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000266412

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
20
C — non-Type-I
64
A — assay feasibility
68
E — evidence strength
23
T1DI (composite)
5
Specificity differential (R−C)-43.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)