NADH Dehydrogenase Ubiquinone Iron-Sulfur Protein 8
NDUFA8geneNDUFA8 mutations or dysregulation impair mitochondrial energy production, exacerbating cardiomyocyte ischemic injury during acute MI.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleMitochondrial respiratory-chain component; dysfunction drives ischemic cardiomyocyte injury and ATP depletion.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000119421
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable