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NEAT1
Pathway / Plaque inflammation

NEAT1

NEAT1rna

NEAT1 modulates inflammatory gene expression and plaque stability through interaction with paraspeckle proteins.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalelncRNA regulates inflammatory pathways in atherosclerotic plaque.
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000245532

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — non-Type-I
64
A — assay feasibility
50
E — evidence strength
24
T1DI (composite)
4
Specificity differential (R−C)-40.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood (transcript)
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)

Literature evidence(1)