NEIL3 DNA Glycosylase
NEIL3geneNEIL3 regulates fibroblast proliferation and DNA repair during myocardial remodeling after infarction, contributing to scar formation and ventricular function.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationalePost-MI remodeling marker; fibroblast proliferation regulation.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.Cell reports · 2017 · PMID 28052262 · doi