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NOS1
Pathway / Endothelial activation & erosion

NOS1

NOS1gene

NOS1 dysregulation impairs nitric oxide production, promoting endothelial dysfunction and macrophage-endothelial interactions in atherosclerosis.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleNitric oxide synthase; endothelial dysfunction in severe CAD.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000089250

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
30
C — non-Type-I
67
A — assay feasibility
52
E — evidence strength
26
T1DI (composite)
4
Specificity differential (R−C)-36.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.261
Open Targets association (acute_MI)

Literature evidence(4)