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Inducible Nitric Oxide Synthase
Pathway / Plaque inflammation

Inducible Nitric Oxide Synthase

NOS2gene

iNOS-driven nitric oxide production in macrophages sustains plaque inflammation and impairs endothelial function.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleM1 macrophage marker in atherosclerotic inflammation; endothelial dysfunction in MI.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates4
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000007171

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
52
E — evidence strength
35
T1DI (composite)
4
Specificity differential (R−C)-52
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuren/a
6hypertensive emergencymag 2
7high-demand / peri-operative stressn/a
Coverage: 1/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 1 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.264
Open Targets association (acute_MI)

Literature evidence(4)