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Endothelial nitric oxide synthase
Pathway / Endothelial activation & erosion

Endothelial nitric oxide synthase

NOS3protein

Endothelial NOS catalyzes NO production essential for vasodilation and platelet inhibition; dysfunction contributes to endothelial erosion and thrombosis.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleProduces NO for endothelial function and vasculoprotection; impairment indicates endothelial dysfunction.
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000164867

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
52
A — assay feasibility
72
E — evidence strength
95
T1DI (composite)
22
Specificity differential (R−C)-36.9
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 1
2hypovolemia / dehydrationmag 1
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 2
2high-demand / peri-operative stressmag 1
3sudden cardiac deathmag 2
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedmag 1
Coverage: 9/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 13 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.312
Open Targets association (acute_MI)
3
GWAS associations
Traits: myocardial infarction

Literature evidence(22)