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Endothelial nitric oxide synthase
Pathway / Endothelial activation & erosion

Endothelial nitric oxide synthase

NOS3protein

Endothelial NOS catalyzes NO production essential for vasodilation and platelet inhibition; dysfunction contributes to endothelial erosion and thrombosis.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleProduces NO for endothelial function and vasculoprotection; impairment indicates endothelial dysfunction.
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000164867

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
52
A — assay feasibility
72
E — evidence strength
95
T1DI (composite)
21
Specificity differential (R−C)-37.4
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 1
3hypovolemia / dehydrationmag 1
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 1
Coverage: 7/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.312
Open Targets association (acute_MI)
3
GWAS associations
Traits: myocardial infarction

Literature evidence(22)